Placental Transfer and Fetal Uptake of Drugs
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چکیده
منابع مشابه
Placental Transfer and Embryo-Fetal Effects of Drugs Used in Anesthesia
Justificativa e Objetivos A anestesia da paciente grávida engloba situações diversas e que devem ser analisadas com muita propriedade. Além da exposição do feto e de uma possível ação tóxica dos agentes a serem utilizados na anestesia, devem ser considerados o período gestacional, as características de cada droga e as doses a serem utilizadas. A falta de informações adequadas sobre o risco do u...
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Mercury vapor is known penetrate the placental barrier more easily than inorganic mercury. A relative amount of mercury accumulates in the fetus after exposure of pregnant animals to mercury vapor. Mercury concentration in fetal organs is much lower than that in maternal organs except the liver, and fetal liver shows significantly higher mercury concentrations than maternal liver. In fetal live...
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FACTORS INFLUENCING PLACENTAL TRANSFER OF LOPINAVIR: BINDING, UPTAKE AND EFFLUX By Abhishek Gulati, B. Pharm., M. Pharm. A Thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2009 Major Director: Phillip M. Gerk, Pharm.D., Ph.D. Assistant Professor, Department of Pharmaceutics HIV ...
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Background & Objective: Due to the relevant use of aspirin to relieve pain and common symptoms of gastric ulcer and possible malicious effects on fetus, this study investigates the histomorphologic effects of aspirin on the stomach tissue in rat embryos. Materials & Methods: In this experimental study, 30 pregnant female rats were randomly divided into six groups including control group wi...
متن کاملRelationship of fetal alanine uptake and placental alanine metabolism to maternal plasma alanine concentration.
Uterine and umbilical uptakes of alanine (Ala) were measured in 10 ewes before (control) and during intravenous infusion of Ala, which increased maternal arterial Ala concentration from 115 ± 14 to 629 ± 78 μM ( P < 0.001). In 8 of these ewes, placental Ala fluxes were traced by constant intravenous infusion ofl-[3,3,3-2H3]Ala in the mother andl-[1-13C]Ala in the fetus. Rates are reported as mi...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1979
ISSN: 0007-0912
DOI: 10.1093/bja/51.suppl_1.25s